G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) C07K 16/28 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2272855
The invention relates to a method for the diagnosis and therapy of Hodgkin- lymphomas (lymphogranulomatosis), which is founded on the expression of the variant exon v10 of the CD44-gene as a molecular marker target. There is a significant correlation between v10-expression and stage as well as prognosis of the disease. In an advantageous embodiment, v10-specific antibody molecules are used to measure the expression of the exon in samples. In a further advantageous embodiment, radio-labelled v10-specific antibodies are used for therapy of Hodgkin lymphomas.
La présente invention concerne un procédé permettant d'effectuer le diagnostic et le traitement des lymphomes hodgkiniens (lymphogranulomatose), qui est fondé sur l'expression de l'exon variant v10 du gène CD44 comme marqueur ou cible moléculaire. Il y a une corrélation importante entre l'expression de v10 et le stade de la maladie et également le pronostic relatif à celle-ci. Selon une forme de réalisation avantageuse, on utilise des molécules d'anticorps spécifiques du v10 pour mesurer l'expression de l'exon dans des échantillons. Selon un autre mode de réalisation avantageux, on utilise des anticorps spécifiques du v10 radiomarqués pour traiter les lymphomes hodgkiniens.
Beham-Schmid Christine
Heider Karl-Heinz
Zatloukal Kurt
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
Forschungszentrum Karlsruhe Gmbh
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