Novel amide and amidine derivatives and uses thereof

Details Novel amide and amidine derivatives and uses thereof Novel amide and amidine derivatives and uses thereof

C - Chemistry, Metallurgy

07

C

C07C 261/04 (2006.01) A61K 31/26 (2006.01) A61P 3/10 (2006.01) A61P 25/00 (2006.01) C07C 257/14 (2006.01)

Patent

CA 2757866

The present invention relates to inhibitors of 11-.beta.-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

La présente invention concerne des inhibiteurs de l'enzyme 11-ß-hydroxystéroïde déshydrogénase de type 1 et leur utilisation dans le traitement du diabète non-insulinodépendant de type 2, de la résistance à l'insuline, de l'obésité, des troubles lipidiques, du syndrome métabolique, de troubles du système nerveux central et de maladies et états qui sont liés à un excès de glucocorticoïdes.

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