A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/48 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01)
Patent
CA 2457250
The present invention relates to a novel thixotropic oily vehicle comprising from 0.2% to 5% (w/w) of a colloidal silica and from 0.2% to 5% (w/W) of a hydrophilic polymer in an edible oil. The interaction between the hydrophylic polymer and the colloidal silicon dioxide in the above concentration ranges enables to keep the amount of the latter component at a low concentration, by nevertheless conferring on the solution enough thixotropy and a low viscosity under shear. The invention also relates to capsules filled with the above fill mass.
L'invention concerne un nouvel excipient huileux thixotrope comprenant 0,2 % à 5 % en poids d'une silice colloïdale et 0,2 % à 5 % en poids d'un polymère hydrophile dans une huile comestible. L'interaction entre le polymère hydrophile et le dioxyde de silicium colloïdal dans les plages de concentration ci-dessus permet de maintenir la quantité du dernier constituant à une faible concentration, tout en conférant à la solution une thixotropie suffisante et une faible viscosité dans des conditions de cisaillement. L'invention concerne également des capsules remplies avec la matière de remplissage ci-dessus.
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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