Viral core protein-cationic lipid-nucleic acid-delivery...

Details Viral core protein-cationic lipid-nucleic acid-delivery... Viral core protein-cationic lipid-nucleic acid-delivery...

C - Chemistry, Metallurgy

12

N

C12N 15/88 (2006.01) A61K 9/127 (2006.01) A61K 47/48 (2006.01) C07K 14/075 (2006.01) C12N 15/34 (2006.01)

Patent

CA 2395454

A nucleic acid delivery complex is provided which comprises a condensed polypeptide/nucleic acid complex and a cationic lipid wherein the complex comprises (a) a nucleic acide sequence of interest (NOI); and (b) one or more viral nucleic acid packaging polypeptides, or derivatives thereof, said polypeptides or derivatives thereof being (i) capable of binding to the NOI; and (ii) capable of condensing the NOI; and wherein the NOI is heterologous to the polypeptide. Also provided is a method of introducing an NOI into a cell using the delivery vector.

L'invention concerne un complexe d'administration d'acides nucléiques, comprenant un complexe acides nucléiques/polypeptide condensé et un lipide cationique, dans lequel le complexe est constitué (a) d'une séquence d'acides nucléiques d'intérêt, et (b) d'un ou plusieurs polypeptides viraux d'enveloppement d'acides nucléiques, ou des dérivés de ceux-ci, ces polypeptides ou dérivés étant (i) capables de se lier aux acides nucléiques d'intérêt, et (ii) capables de condenser ces acides nucléiques. Dans l'invention, les acides nucléiques d'intérêt sont hétérologues au polypeptide. L'invention concerne aussi une méthode d'introduction des acides nucléiques d'intérêt dans une cellule au moyen du vecteur.

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