Anti-nkg2a antibodies and uses thereof

Details Anti-nkg2a antibodies and uses thereof Anti-nkg2a antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2655623

Described herein are anti-NKG2A antibodies suitable for human therapy, including humanized versions of murine anti-NKG2A antibody Z270, as well as related methods and materials for producing and using such antibodies. Exemplary complementarity-determining regions (CDRs) sequences and sites for optional amino acid back-substitutions in framework region (FR) and/or CDRs of such antibodies are also described.

La présente invention concerne des anticorps anti-NKG2A appropriés à une thérapie humaine, y compris des versions humanisées d'anticorps anti-NKG2A murins Z270, aussi bien que des procédés et des matériaux connexes permettant la production et l'utilisation de tels anticorps. L'invention concerne également des séquences et des sites exemplaires de régions de détermination de complémentarité (CDR) destinés à d'éventuelles rétro-substitutions d'acides aminés dans la région charpente (RC) et/ou les CDR de tels anticorps.

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