Oxidative denaturation of protein analytes

Details Oxidative denaturation of protein analytes Oxidative denaturation of protein analytes

G - Physics

01

N

195/37

G01N 33/574 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2019671

A method for conferring or increasing the antigenicity of a disulfide-crosslinked protein by treating the protein with an oxidizing agent, such as periodate, having an oxidation potential sufficient to cleave disulfide linkages. Excess oxidizing agent is then inactivated by addition of a reducing agent. The resulting protein exhibits an increase in its ability to be bound by select antibodies, particularly monoclonal antibodies directed to linear peptide epitopes in the protein.

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