Pre-storage filtration of platelets

Details Pre-storage filtration of platelets Pre-storage filtration of platelets

A - Human Necessities

61

K

167/114

A61K 35/16 (2006.01) A61M 1/02 (2006.01) A61M 1/34 (2006.01)

Patent

CA 2035929

Filtration of white blood cells (WBCs) directly from platelet rich plasma (PRP) rather than from subsequently made platelet concentrates (PC). Earlier filtration is effective at removing most WBCs with minimal platelet loss and permits storage of platelets for at least 5 days. The filtration is preferably done with a closed, ready-to-use system comprising a WBC filter disposed between a first blood bag and at least two empty secondary bags. A fourth bag may be included in the closed system to contain a platelet additive solution. System can remove at least 95% of the WBCs with less than 10% loss in platelets. In very preferred embodiments at least 99.5% of the original WBCs are removed by filtration prior to platelet storage.

Filtration des leucocytes directement à partir du plasma riche en plaquettes plutôt qu'à partir de concentrés de plaquettes fabriqués après coup. Cette filtration précoce réussit à éliminer la plupart des leucocytes avec une perte minimale de plaquettes, et permet de conserver les plaquettes durant au moins 5 jours. Idéalement, la filtration se fait à l'aide d'un système fermé prêt à être utilisé, composé d'un filtre à leucocytes placé entre un premier sac de sang et au moins deux autres sacs secondaires vides. Un quatrième sac peut être adjoint au système fermé pour contenir une solution adjuvante de plaquettes. Le système permet d'éliminer au moins 95 % des leucocytes en perdant moins de 10 % des plaquettes. Dans les installations idéales, au moins 99,5 % des leucocytes d'origine sont éliminés par filtration avant le stockage des plaquettes.

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