Low calcemic, highly antiproliferative, analogs of calcitriol

Details Low calcemic, highly antiproliferative, analogs of calcitriol Low calcemic, highly antiproliferative, analogs of calcitriol

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) A61P 17/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2684741

The disclosure provides compounds, compositions and methods using these compounds and compositions to stimulate the differentiation of cells and inhibit excessive cell proliferation of certain cells, including cancer cells and skin cells, which may be useful in the treatment of diseases characterized by abnormal cell proliferation and/or cell differentiation such as leukemia, myelofibrosis and psoriasis without the well known effect on calcium metabolism, which gives rise to hypercalcemia.

L'invention concerne des composés, des compositions et des procédés utilisant ces composés et compositions pour stimuler la différenciation de cellules et empêcher la prolifération cellulaire excessive de certaines cellules, y compris des cellules cancéreuses et des cellules épithéliales, qui peuvent être utiles dans le traitement de maladies caractérisées par la prolifération cellulaire anormale et/ou la différenciation de cellules telle que la leucémie, la myélofibrose et le psoriasis sans l'effet bien connu sur le métabolisme du calcium, qui provoque l'hypercalcémie.

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