Treating immunological disorder using agonists of...

Details Treating immunological disorder using agonists of... Treating immunological disorder using agonists of...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/42 (2006.01) A61K 31/436 (2006.01) A61K 31/519 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61P 25/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2518854

Methods and compositions for modulating interleukin-21 (IL-21)/IL-21 receptor (MU-1) activity using agonists of IL-21 or IL-21 receptor ("IL-21R" or "MU- 1"), are disclosed. IL-21/IL-21R agonists can be used by themselves or in combination with 5 anti-inflammatory agents to treat, e.g., ameliorate, symptoms associated with immunological disorders of the nervous system, e.g., multiple sclerosis.

L'invention concerne des méthodes et des compositions permettant de moduler l'activité de l'interleukine-21 (IL-21)/ du récepteur de l'IL-21 (MU-1) à l'aide d'agonistes de l'IL-21 ou du récepteur de l'IL-21 ("IL-21R" ou "MU-1"). Les agonistes de l'IL-21/ de l'IL-21R peuvent être utilisés seuls ou associés à des agents anti-inflammatoires afin de traiter, par exemple, de soulager, des symptômes associés aux troubles immunologiques du système nerveux, par exemple, la sclérose en plaques.

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