C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2269799
A method for breeding mutagenized mice that permits detection of genetic loci that can modify a known index phenotype involves crossing a mutagenized founder strain and a second strain of mice carrying an allele at a locus that confers the index phenotype. In the test generation, clusters of individuals are observed to deviate from the typical phenotype. The genetic material and molecules encoded thereby can be obtained using available methods.
L'invention concerne un procédé destiné à l'élevage de souris mutagénisées, permettant de détecter des loci génétiques pouvant modifier un phénotype index connu, qui consiste à croiser une souche fondatrice mutagénisée avec une seconde souche de souris portant un allèle à un locus qui confère le phénotype index. Dans la génération testée, on observe des groupes d'individus s'écartant du phénotype type. On peut obtenir le matériel génétique et les molécules ainsi codées en utilisant les procédés actuellement disponibles.
Dove William F.
Shedlovsky Alexandra
Gowling Lafleur Henderson Llp
Wisconsin Alumni Research Foundation
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