Modulating regulatory t cell activity via interleukin 35

Details Modulating regulatory t cell activity via interleukin 35 Modulating regulatory t cell activity via interleukin 35

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61P 37/04 (2006.01) C07K 14/54 (2006.01) C07K 14/715 (2006.01)

Patent

CA 2664423

Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35 -specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine.

L'invention concerne des procédés servant à moduler la fonction des lymphocytes T chez un sujet, en particulier l'activité régulatrice des lymphocytes T. Les procédés de l'invention consistent à administrer à un sujet une quantité efficace du point de vue thérapeutique d'un agent fixant spécifiquement l'interleukine 35, tel qu'un anticorps ou un inhibiteur dont la molécule a une petite taille. L'invention concerne en outre des procédés servant à accroître l'immunogénicité d'un vaccin ou à surmonter le problème de suppression de réponse immunitaire à un vaccin chez un sujet, consistant à administrer au sujet une quantité efficace du point de vue thérapeutique d'un agent fixant spécifiquement l'IL35 et à administrer un vaccin au sujet. Dans un mode de réalisation le vaccin est un vaccin contre le cancer.

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