Tricyclic derivatives

Details Tricyclic derivatives Tricyclic derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2127411

The invention concerns tricyclic derivatives of the formula I (see formula I) wherein R1 and R2 together form an optionally substituted group of the formula -N=CH-NH-, -N=CH-O-, -N=CH-S-, -N=N-NH-, -NH-N=CH-, -NH-CH=CH-. -NH-CO-NH-, -NH-CO-O-, -NH-CO-S-, -NH-NH-CO-, -N=CH-CH=N-, -N=N-CH=CH-, -N=CH-N=CH-, -N=CH-CH=N-, -NH-CO-CH=CH- or -N=CH-CO-NH-; m is 1, 2 or 3 and R3 includes hydrogen, halogeno and (1-4C)alkyl; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them; and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of cancer.

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