Formulations of radioprotective .alpha., .beta. unsaturated...

A - Human Necessities – 61 – K

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A61K 31/10 (2006.01) A61K 31/277 (2006.01) A61K 31/341 (2006.01) A61K 31/381 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61P 17/16 (2006.01)

Patent

CA 2659222

Solution and suspension formulations are provided for administration prior to or after exposure to ionizing radiation for reducing toxic effects of the radiation in a subject which comprises an effective amount of at least one radioprotective .alpha., .beta. unsaturated aryl sulfone wherein the composition has a pH within the range of about 8 to about 9.

La présente invention concerne des formulations en solution et en suspension destinées à être administrées avant ou après exposition à un rayonnement ionisant afin de réduire les effets toxiques du rayonnement chez un sujet. Lesdites formulations comprennent une quantité efficace d'au moins une arylsulfone .alpha.,.beta.-insaturée radioprotectrice, la composition ayant un pH dans la plage d'environ 8 à environ 9.

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