Novel treatment for eye disease

Details Novel treatment for eye disease Novel treatment for eye disease

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 41/00 (2006.01)

Patent

CA 2395567

This invention discloses methods, kits, and instructions to treat neovasculature diseases of the eye through the administration of a targeted photosensitizing agent and subsequent exposure to light of specific wavelength sufficient to photoactivate photosensitizing agent. The photosensitizing agent is bound to a composition that mediates site specific delivery to a neovasculature target tissue of a therapeutically effective amount of a photosensitizing agent that is activated by a relatively low fluence rate of light over a prolonged period of time. Diseases treatable under this invention, include: diabetic retinopathy; macular degeneration; and malignant uveal melanomas.

L'invention concerne des procédés, des kits et des instructions pour le traitement de maladies néovasculaires de l'oeil, par l'administration d'un agent photosensibilisant ciblé, puis par l'exposition à une lumière d'une longueur d'onde spécifique suffisante pour la photoactivation de l'agent photosensibilisant. L'agent photosensibilisant est lié à une composition qui participe à la libération <= site-spécifique >=, à un tissu cible néovasculaire, d'une dose thérapeutiquement efficace d'un photosensibilisant activé par une fluence faible de lumière sur une période prolongée. Les maladies pouvant être traitées par les méthodes de l'invention sont, entre autres, la rétinopathie diabétique, la dégénérescence pigmentaire de la macula, et les mélanomes uvéaux malins.

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