A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/50 (2006.01) A61K 31/135 (2006.01) A61K 31/17 (2006.01) A61K 31/475 (2006.01) A61K 31/513 (2006.01) A61K 31/704 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2493282
Improvements in methods of treating cancer with weakly basic anti-cancer compounds are provided. In one aspect, the invention provides an improvement in a method of treating cancer cells whose extracellular environment contains 1-8 mM urea, by exposing the cells to a weakly basic anti-cancer compound which is effective in inhibiting the growth of the cells. The improvement includes (a) exposing the cells to a urease enzyme composition and, (b) by step (a), reducing the amount of anti- cancer compound required to produce a given extent of inhibition in the growth of the cells when the cells are exposed to the anti-cancer agent. Methods of potentiating the specific therapeutic activity of a weakly basic anti-cancer compound in the treatment of a given mammalian cancer which is responsive to the compound are provided as are pharmaceutical compositions for use in intravenous administration to a subject are also provided.
Chao Heman
Dickstein Jodi
Docherty John
Mcelroy Jerry
Segal Donald
Gowling Lafleur Henderson Llp
Helix Biopharma Corp.
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