A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4375 (2006.01) A61K 31/27 (2006.01) A61K 31/445 (2006.01) A61K 31/473 (2006.01) A61K 31/55 (2006.01) A61K 45/00 (2006.01) A61P 9/10 (2006.01) A61P 25/00 (2006.01) A61P 25/02 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2562694
A medicine which comprises a combination of an acetylcholine esterase inhibitor and a 5-substituted 3-oxadiazolyl-1,6-naphthyridin-2(1H)-one derivative represented by the following general formula (I). It is useful for the treatment of memory disorders accompanying neuropsychiatric diseases and other cognition disorders. Also provided are: a method of treatment of any of these diseases which comprises using a combination of these drugs; and a use of the medicine. (In the formula (I), Het is oxadiazolyl; R1 is hydrogen, lower alkyl, cyclo(lower alkyl), lower alkenyl, lower alkoxy, (un)substituted aryl, (un)substituted heteroaryl, etc.; and R2 is hydrogen, lower alkyl, cyclo(lower alkyl), (un)substituted aryl, etc.)
Médicament lequel comprend une association d'un inhibiteur d'acétylcholine estérase et d'un dérivé de 3-oxadiazolyl-1,6-naphthyridin-2(1H)-one substitué en position 5 représenté par la formule générale (I) suivante. Il est utile pour le traitement de troubles de la mémoire accompagnant des maladies neuropsychiatriques et d'autres troubles des connaissances. Il est également fourni : un procédé de traitement de l'une quelconque de ces maladies lequel comprend d'utiliser une association de ces médicaments ; et l'utilisation du médicament. (dans la formule (I) Het est un oxadiazolyle ; R?1¿ est un hydrogène, un alkyle inférieur, un cyclo(alkyle inférieur), un alcényle inférieur, un alcoxy inférieur, un aryle substitué ou non, un hétéroaryle substitué ou non, etc. ; et R?2¿ est un hydrogène, un alkyle inférieur, un cyclo(alkyle inférieur), un aryle substitué ou non, etc.)
Furukawa Kiyoshi
Hashimoto Takashi
Kurumiya Satoshi
Dainippon Sumitomo Pharma Co. Ltd.
Kirby Eades Gale Baker
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