Drug complex

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/06 (2006.01) A61K 31/4745 (2006.01) A61K 47/36 (2006.01) A61K 47/48 (2006.01) C07D 471/14 (2006.01) C07D 491/22 (2006.01) C07K 5/00 (2006.01) C07K 5/103 (2006.01)

Patent

CA 2333321

Drug composites useful as DDS compounds, which are represented by the general formula: A-R-NH-Y-CH2-O-CO-Q (wherein A is a polymer serving as a carrier for a drug; R is a spacer comprising one amino acid molecule or one comprising 2 to 8 amino acid molecules bound to each other through peptide linkage; Y is optionally substituted phenylene; and Q is a residue of a drug compound such as an antitumor agent). The composites permit the speedy and regioselective release of drug compounds such as antitumor or anti-inflammatory agents, thus exhibiting expected drug effects without fail.

Composites médicamenteux utiles en tant que composés DDS, représentés par la formule générale :A-R-NH-Y-CH¿2?-O-CO-Q (dans laquelle A représente un polymère servant de véhicule pour un médicament ; R représente un espaceur comprenant une molécule d'acide aminé ou comprenant 2 à 8 molécules d'acide aminé liées les unes aux autres par une liaison peptidique ; Y représente phénylène éventuellement substitué ; et Q représente un reste de composé médicamenteux, tel qu'un agent antitumoral). Lesdits composites permettent la libération rapide et régiosélective de composés médicamenteux, tels que des agents antitumoraux ou anti-inflammatoires, et présentent les effets attendus, sans défaillance.

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