New thrombin inhibitors, their preparation and use

Details New thrombin inhibitors, their preparation and use New thrombin inhibitors, their preparation and use

C - Chemistry, Metallurgy

07

D

C07D 205/04 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/695 (2006.01) C07D 207/16 (2006.01) C07D 211/60 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07F 7/10 (2006.01) C07D 405/00 (2006.01)

Patent

CA 2226256

There is provided amino acid derivatives of formula (I), wherein p, q, R1, R2, R3, R4, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

On décrit des dérivés d'acides aminés, de la formule (I), dans laquelle p, q, R<1>, R<2>, R<3>, R<4>, Y, n et B possèdent les notations données dans la description. Ces dérivés sont utiles en tant qu'inhibiteurs compétitifs de protéases du type trypsine, telles que la thrombine, et ce notamment dans le traitement d'états dans lesquels on veut inhiber la thrombine (par exemple dans la thrombose), ou en tant qu'anticoagulants.

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