A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61P 3/10 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2384982
The invention relates to the use of hymenialdisine or derivatives thereof of formula (I) in which R1 and R2, identical or different, represent H or Br, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in inhibiting acceptable salt thereof, in the manufacture of a medicament for use in inhibiting cycline dependent kineases, GSK-3.beta. and casein kinase 1. Application for preventing and treating neurodegenerative disorders, including Alzheimers disease, diabetes, inflammatory pathologies and cancers.
L'invention concerne l'utilisation d'hymenialdisine ou de ses dérivés représentés par la formule (I) dans laquelle R1 et R2, identiques ou différents, représentent H ou Br, ou un de leurs sels pharmaceutiquement acceptables, pour la fabrication d'un médicament servant à inhiber les kinases cycline-dépendantes GSK-3.beta. et la caséine kinase 1. L'invention trouve des applications dans le traitement et la prévention des troubles neuro-dégénératifs, du diabète, de pathologies inflammatoires et du cancer.
Centre National de La Recherche Scientifique (c.n.r.s.)
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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