Method for quantitative determination of fas antigen

Details Method for quantitative determination of fas antigen Method for quantitative determination of fas antigen

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) G01N 33/564 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2164374

The present invention relates to a polyclonal antibody or a monoclonal antibody which is obtained by using, as the immunogen, a synthetic peptide having the following sequence (a part of which may be modified or deleted) or a soluble Fas antigen containing an intracellular region. Cys-Asn-Ile-Thr-Ser-Asp-Ser-Gln-Asn-Ser-Asn-Phe-Arg- Asn-Glu-Ile-Gln-Ser-Leu-Val These antibodies specifically recognize the intracellular region of a Fas antigen. By measuring a Fas antigen according to sandwich ELISA using any of these antibodies, it is possible to diagnose autoimmune diseases such as SLE, RA, etc.

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