Use of squalamine for the manufacture of a medicament for...

Details Use of squalamine for the manufacture of a medicament for... Use of squalamine for the manufacture of a medicament for...

A - Human Necessities

61

K

A61K 31/575 (2006.01)

Patent

CA 2223908

Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.

L'invention concerne des composés d'aminostérols utiles en tant qu'inhibiteurs de l'échangeur sodium/proton (NHE). L'invention concerne également des modes d'utilisation de ces composés d'aminostérol, y compris ceux utilisant des composés constituant des inhibiteurs d'un spectre des NHE, ainsi que ceux utilisant des composés constituant des inhibiteurs uniquement d'un NHE spécifique. L'invention concerne en outre des technique de criblage ainsi que des dosages d'évaluation avantageux de l'activité thérapeutique d'un composé.

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