C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/078 (2006.01) A61K 38/05 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2290748
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
Cette invention concerne des composés qui se lient à l'intégrine VLA-4. Certains de ces composés inhibent également l'adhésion des leucocytes et, en particulier, l'adhésion des leucocytes induite par la VLA-4. Ces composés sont utilisés pour traiter des maladies inflammatoires chez un patient mammifère, par exemple, un être humain. Parmi ces maladies, on trouve l'asthme, la maladie d'Alzheimer, l'athérosclérose, le complexe démentiel du SIDA, le diabète, l'affection intestinale inflammatoire, la polyarthrite rhumatoïde, la transplantation de tissus, la métastase tumorale et l'ischémie myocardique. Ces composés peuvent également être administrés pour traiter des maladies cérébrales inflammatoires telles que la sclérose en plaques.
Baudy Reinhardt Bernhard
Grant Francine S.
Konradi Andrei W.
Kreft Anthony
Pleiss Michael A.
American Home Products Corporation
Elan Pharmaceuticals Inc.
Torys Llp
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