Therapeutic monoclonal antibodies that neutralize botulinum...

Details Therapeutic monoclonal antibodies that neutralize botulinum... Therapeutic monoclonal antibodies that neutralize botulinum...

C - Chemistry, Metallurgy

07

K

C07K 16/12 (2006.01) A61K 39/395 (2006.01) C12N 15/13 (2006.01) C07K 16/40 (2006.01)

Patent

CA 2594297

This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A(BoNT/ A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

La présente invention concerne des anticorps qui se lient spécifiquement à et neutralisent la neurotoxine botulique de type A (BoNT/A), ainsi que les épitopes liés par ces anticorps. Ces anticorps et leurs dérivés et/ou d'autres anticorps qui se lient spécifiquement aux épitopes neutralisants selon l'invention peuvent être utilisés pour neutraliser la neurotoxine botulique et sont donc utiles dans le traitement du botulisme.

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