Triazole compounds, their production and use

Details Triazole compounds, their production and use Triazole compounds, their production and use

C - Chemistry, Metallurgy

07

D

167/208, 260/271

C07D 403/12 (2006.01) A61K 31/395 (2006.01) C07C 45/46 (2006.01) C07C 45/63 (2006.01) C07C 45/64 (2006.01) C07C 45/67 (2006.01) C07C 49/80 (2006.01) C07C 49/807 (2006.01) C07C 49/82 (2006.01) C07D 249/08 (2006.01) C07D 309/12 (2006.01) C07D 401/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2026143

Disclosed are 2-(2,4-difluorophenyl)-1-(1H-1,2,4- triazol-1-yl)-2-propanol derivatives of the formula: Image (wherein R0, R1 and R2 are each hydrogen or lower alkyl; A is -S(O)n-X-R3 or -S-R4; n is 0, 1 or 2; R3 is heteroaromatic group; R4 is hydrogen or alkanoyl; X is a bond or -CR5R6-X1-; X1 is a bond or alkylene group; and R5 and R6 are each hydrogen or lower alkyl) useful for preventing or treating infectious diseases cased by fungi. Also disclosed are novel compounds of the formulae: Image Image all useful as intermediates for producing the 2-(2,4- difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-propanol derivatives.

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