A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2690888
The present invention relates to a pharmaceutical composition for cancer treatment, which comprises an antibody against a peptide region encoded by Exon-17 of periostin. More specifically, the present invention relates to a pharmaceutical composition for cancer treatment, which comprises an anti-periostin antibody recognizing a splice variant of periostin having anti-cell adhesive properties specifically expressed in interstitial tissue during tissue restructuring such as cancer tissues, or a method and reagent for cancer diagnosis using the above anti-periostin antibody.
La présente invention concerne une composition médicinale permettant de traiter le cancer, la composition contenant un anticorps dirigé contre une région peptidique codée par l'exon-17 de la périostine. De façon plus spécifique, l'invention concerne une composition qui permet de traiter le cancer et contient un anticorps anti-périostine capable de reconnaître un variant d'épissage de la périostine produisant un effet d'anti-adhérence cellulaire, exprimé de façon spécifique dans l'espace interstitiel d'un tissu en reconstruction tel qu'un tissu cancéreux. L'invention porte également sur un procédé de diagnostic et sur un diagnostic de cancer grâce à l'utilisation de l'anticorps anti-périostine décrit précédemment.
Katsuragi Naruto
Morishita Ryuichi
Taniyama Yoshiaki
Asubio Pharma Co. Ltd.
Daiichi Sankyo Company Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Osaka University
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