C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/12 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61K 31/495 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/53 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) C12Q 1/18 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) C12N 9/02 (2006.01) C12N 9/12 (2006.01)
Patent
CA 2584057
The invention provides therapeutic and prophylactic compounds and methods for altering the activity of pyruvate dehydrogenase kinase (e.g. PDK1, PDK2, PDK3, PDK4). Such therapies are useful for the treatment of neoplasia. The invention further provides therapeutic and prophylactic compounds and methods of altering pyruvate dehydrogenase activity to treat or prevent cell death related to ischemia.
L'invention concerne des composés thérapeutiques et prophylactiques ainsi que des méthodes permettant de modifier l'activité de la pyruvate déshydrogénase kinase (par exemple, PDK1, PDK2, PDK3, PDK4). Ces thérapies sont utiles pour le traitement de la néoplasie. L'invention concerne également des composés thérapeutiques et prophylactiques et des méthodes permettant de modifier l'activité de la pyruvate déshydrogénase kinase afin de traiter ou de prévenir la mort cellulaire associée à l'ischémie.
Dang Chi V.
Kim Jung-Whan
Semenza Gregg
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Johns-Hopkins University
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