Potent t cell modulating molecules

Details Potent t cell modulating molecules Potent t cell modulating molecules

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/725 (2006.01) C07K 16/00 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2403313

The present invention relates to a polypeptide construct comprising at least one CDR3 region, wherein at least one of the at least CDR3 regions comprises at least one substitution in the amino acid sequence YYDDHY (SEQ ID NO.1) and wherein the at least one substitution comprises: in the first position of SEQ ID NO.1 a substitution from Y to H; in the second position of SEQ ID NO. 1 a substitution from Y to S, from Y to N, from Y to F or from Y to H; in third position of SEQ ID NO. 1 a substitution from D to N or from D to E; in the forth position of SEQ ID NO. 1 a substitution from D to Q, from D to A, from D to V, from D to E or from D to G; in the fifth position of SEQ ID NO. 1 a substitution from H to Q, from H to P, from H to Y, from H to R or from H to N; or in the sixth position a substitution from Y to N.

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