C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/54 (2006.01) A61K 31/197 (2006.01) A61K 31/4425 (2006.01) A61K 31/495 (2006.01) A61K 31/5375 (2006.01) A61K 39/39 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07C 229/12 (2006.01) C07D 241/12 (2006.01) C07D 295/04 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2501318
Basic esters of fatty alcohols of the general formula: R1-O-CO-A or pharmaceutically acceptable salSt thereof, wherein R1 is C12-C24 alkyl or C10- C24 alkenyl, and A is a residue containing at least one acyclic or cyclic amino group and/or at least one heteroaromatic ring containing a tertiary or quaternary nitrogen atom, are anti-inflammatory and immunomodulatory agents, useful in the treatment of immunologically-mediated inflammation, and as adjuvants for antigens involved in both cellular and humoral responses.
L'invention concerne des esters de base d'alcools gras de formule générale R1-O-CO-A ou leurs sels pharmaceutiquement acceptables dans laquelle R1 désigne alkyle C¿12?-C¿24? ou alcényle C¿10?-C¿24?, et A désigne un résidu contenant au moins un groupe amino acyclique ou cyclique et/ou au moins un cycle hétéroaromatique contenant un atome d'azote tertiaire ou quaternaire. Les esters de base de cette invention servent d'agents anti-inflammatoires et immunomodulateurs que l'on utilise dans le traitement d'inflammations induites de manière immunologique et d'adjuvants pour antigènes impliqués à la fois dans les réponses cellulaires et humorales.
Cohen Irun R.
Herzig Yaacov
Margalit Raanan
Miskolczi Istvan
Rantal Ferenc
Heenan Blaikie Llp
Yeda Research And Development Co. Ltd
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