Vectors and viral vectors, and packaging cell lines for...

Details Vectors and viral vectors, and packaging cell lines for... Vectors and viral vectors, and packaging cell lines for...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) C12N 5/071 (2010.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 15/861 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2596292

Provided are novel vectors and viral vectors capable of expressing genes or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial cells, liver cells and the like. The nucleic acid components of the vectors may include one or more native promoter/enhancer regions having modified sequence segments, one or more non--native promoter/enhancer or non-native promoter's gene or gene segment, and a native viral terminator or processing signal or segment thereof (see Figure 8). The viral vectors comprise a virus or viral portion having on the surfaces or envelopes adsorption components, one for a packaging cell line and the other for delivery to a target cell. Packaging cell lines for proprogating the vectors and viral vectors are also provided, as are novel processes for propagating any of the disclosed vectors or viral vectors.

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