C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 39/00 (2006.01) C07K 14/475 (2006.01) C07K 16/18 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2563393
The present invention relates to polypeptide fragments capable of raising a specific T-cell response, wherein said fragment comprises a peptide consisting of at least 9 consecutive amino acid residues of ML-IAP as well as to said fragments for use as medicaments. The invention furthermore relates to use of said polypeptide frag-ments in the manufacture of a medicament for treatment of a clinical condition, such as cancer. The invention also relates to methods of selecting a peptide comprising a fragment of ML-IAP for use in a vaccine composition as well as to vaccine composi-tions comprising isolated ML-IAP (SEQ ID NO:1) and/or one or more fragments thereof.
La présente invention concerne des fragments de polypeptides capables de déclencher une réponse spécifique des lymphocytes T, lesdits fragments comprenant un peptide composé d'au moins 9 résidus d'amino-acides consécutifs de ML-IAP ainsi que l'utilisation de ces fragments dans des médicaments. L'invention concerne en outre l'utilisation desdits fragments de polypeptides pour la fabrication de médicaments pour le traitement d'un état pathologique tel que le cancer. Cette invention porte également sur des méthodes de sélection d'un peptides comprenant un fragment de ML-IAP pour utilisation dans une composition de vaccin ainsi que des compositions de vaccin comprenant un ML-IAP (SEQ ID NO:1) isolé et/ou un ou plusieurs fragments de ML-IAP.
Andersen Mads Hald
Straten Per Thor
Deeth Williams Wall Llp
Survac Aps
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