Method for preparing a-(4-isobutylphenyl) propionic acid or...

Details Method for preparing a-(4-isobutylphenyl) propionic acid or... Method for preparing a-(4-isobutylphenyl) propionic acid or...

C - Chemistry, Metallurgy

07

C

260/478.7, 260/5

C07C 47/228 (2006.01) C07C 5/333 (2006.01) C07C 45/50 (2006.01) C07C 45/62 (2006.01) C07C 51/14 (2006.01) C07C 51/255 (2006.01) C07C 57/30 (2006.01)

Patent

CA 2005845

A method for preparing .alpha.-(4-isobutylphenyl) propionic acid or its precursor is here disclosed which comprises a step (I) of dehydrogenating p-isobutylethyl-benzene in a gaseous phase in the presence of a dehydrogenating metal catalyst to form p-isobutylstyrene and at least one unsaturated hydrocarbon compound selected from the group consisting of 4-(2'-methyl-1'- propenyl)ethylbenzene, 4-(2'-methyl-1'-propenyl) vinylbenzene, 4-(2'-methyl-2'-propenyl)ethylbenzene, and 4-(2'-methyl-2'-propenyl)vinylbenzene; a step (II) of reacting p-isobutyl-styrene obtained in the step (I) with carbon monoxide and hydrogen or with carbon monoxide and water or a lower alcohol in the presence of a transition metal complex carbonylating catalyst to form .alpha.-(4-isobutylphenyl)propionic acid or its precursor; and a step (III) of hydrogenating at least one unsaturated hydrocarbon compound selected from the group A obtained in the dehydrogenation step (I) to form p-isobutylethylbenzene, and recycling the thus formed p-isobutylethylbenzene through the step (I) as the raw material of the step (I). The .alpha.-(4-isobutylphenyl) propionic acid so prepared is useful as a medicine (an analgesic).

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