Arylsulfonylamino hydroxamic acid derivatives

Details Arylsulfonylamino hydroxamic acid derivatives Arylsulfonylamino hydroxamic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 311/19 (2006.01) A61K 31/18 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 295/185 (2006.01) C07D 309/14 (2006.01) C07D 335/02 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 471/08 (2006.01) C07D 473/00 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2244501

Disclosed is a compound of the formula: (see fig. I) (wherein n is 1-6; X is hydroxyl, alkoxy or optionally substituted amino; R3 and R4 are each hydrogen, alkyl aryl or the like; and Ar is aryl-aryl), which inhibits matrix metalloproteinase and production of TNF and is useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis, bone resorption, loosening of artificial joint implants, atherosclerosis, multiple sclerosis, occular angiogenisis and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF.

Divulgation concernant un composé de formule (voir fig. I), où : n est 1-6; X est un hydroxyle, un alcoxy ou un amino avec substitution facultative; R3 et R4 sont chacun un hydrogène, un alkylaryle ou un groupe de même type; Ar est un arylaryle. Ledit composé est un inhibiteur de la métalloprotéinase matricielle et de la production de FNT, et il est utile pour le traitement des affections suivantes : arthrite, cancer, ulcération des tissus, resténose, parodontopathie, épidermolyse bulleuse, sclérite, résorption osseuse, descellement d'implants articulaires, athérosclérose, sclérose en plaques, angiogenèse oculaire et autres maladies caractérisées par l'activité de la métalloprotéinase matricielle; SIDA, septicémie, choc septique, et autres maladies caractérisées par la production de FNT.

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