Retroviral vectors containing internal ribosomal entry sites

Details Retroviral vectors containing internal ribosomal entry sites Retroviral vectors containing internal ribosomal entry sites

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) C12N 9/02 (2006.01) C12N 9/78 (2006.01) C12N 9/88 (2006.01) C12N 15/67 (2006.01) C12N 15/86 (2006.01) C12N 15/867 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2424738

The present invention relates to retroviral vector genomes and to vector systems comprising such genomes. In particular the present invention relates to a retroviral vector genome comprising two or more NOIs operably linked by one or more Internal Ribosome Entry Site(s); a lentiviral vector genome comprising two or more NOIs suitable for treating a neurodegenerative disorder; and a lentiviral vector genome which encodes tyrosine hydroxylase, GTP-cyclohydrolase I and optionally Aromatic Amino Acid Dopa Decarboxylase.

La présente invention concerne des génomes de vecteurs de rétrovirus et des systèmes de vecteurs comprenant de tels génomes et concerne plus particulièrement un génome de vecteur rétroviral comprenant au moins deux séquences nucléotidiques intéressantes (SNI) fonctionnellement liées par au moins une séquence IRES; un génome de vecteur lentiviral comprenant au moins deux SNI adapté pour traiter une maladie neurodégénérative; un génome de vecteur lentiviral qui code la tyrosine hydroxylase, la GTP-cyclohydrolase I et facultativement la Dopa décarboxylase d'acide aminé aromatique.

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