Melanoma and prostate cancer specific antibodies for...

Details Melanoma and prostate cancer specific antibodies for... Melanoma and prostate cancer specific antibodies for...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 16/30 (2006.01) C07K 16/40 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2256310

Methods and compositions are provided for detecting antigens having a specific epitope associated with melanoma and prostatic carcinoma. The epitope is present in melanoma cells and prostatic cancer cells but is essentially absent from melanocytes and normal prostatic tissue. The antibody can be used in diagnostic methods for histochemical detection of human melanoma and prostate carcinoma, of various progression stages and in treatment of melanoma and prostate carcinoma.

L'invention concerne des méthodes et des compositions permettant de détecter des antigènes possédant un épitope spécifique associé au mélanome et au carcinome de la prostate. Cet épitope est présent dans les cellules du mélanome et du cancer de la prostate, mais est sensiblement absent des mélanocytes et du tissu prostatique normal. L'anticorps peut être utilisé pour des méthodes diagnostiques permettant la détection histochimique du mélanome et du carcinome de la prostate chez l'homme, la détection des différents stades d'évolution, ainsi que pour le traitement du mélanome et du carcinome de la prostate.

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