Ornithine decarboxylase inhibiting cyclic aminooxy compounds

Details Ornithine decarboxylase inhibiting cyclic aminooxy compounds Ornithine decarboxylase inhibiting cyclic aminooxy compounds

C - Chemistry, Metallurgy

07

C

C07C 239/20 (2006.01) A61K 31/13 (2006.01)

Patent

CA 2135782

2135782 9424093 PCTABS00034 Compounds of the formula (I): H2N-(CH2)n-A-(CH2)m-O-NH2 and salts thereof are described in which the radical A is C3-C6cycloalkylene; n is 0 or 1 and, independently thereof, m is 0 or 1; with the provisos that a) the distance between the aminooxy radical H2N-O- and the amino group -NH2 is at least 3 and not more than 4 carbon atoms and that b) the two radicals H2N-(CH2)n- and -(CH2)m-O-NH2 are not bonded to the same ring carbon atom of A. The compounds of formula (I) and their salts are ornithine decarboxylase inhibitors.

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