Use of tyrosine kinase inhibitors to treat diabetes

Details Use of tyrosine kinase inhibitors to treat diabetes Use of tyrosine kinase inhibitors to treat diabetes

A - Human Necessities

61

K

A61K 31/506 (2006.01) A61K 31/404 (2006.01) A61K 31/42 (2006.01) A61K 31/437 (2006.01) A61K 31/47 (2006.01) A61K 31/498 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 38/12 (2006.01) A61K 38/19 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2526594

The invention relates to the use of a c-Abl-. PDGF-R-, or c-kit- tyrosine kinase inhibitor, e.g. 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4- pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide, Bis (1H-2-indolyl)-1- methanones, AG1295, CT52923, RP-1776; GFB-111; pyrrolo[3,4-c]-beta-carboline- diones, SU 102, AG1296, RPR101511A, CDP 860, Zvegf3, CP673451, PD 170262, KI 6783, KN 1022, AG 13736, CHIR 258, MLN 518, SU 11248, Leflunomide, or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of diabetes, e.g. type I diabetes, type II diabetes.

L'invention porte sur l'utilisation d'un inhibiteur de tyrosine kinase c-Abl-. PDGF-R- ou c-kit-, tel que 4-(4-méthylpipérazin-1-ylméthyl)-N-[4-méthyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phényl]-benzamide, ou des sels de celui-ci acceptables d'un point de vue pharmaceutique dans la fabrication d'un médicament destiné à être utilisé dans le traitement du diabète, comme le diabète de type I et le diabète de type II.

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