Substituted quinolines as protein tyrosine kinase enzyme...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 417/12 (2006.01) A61K 31/4709 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 215/54 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2537978

This invention provides compounds of formula (I), having the structure wherein R1, R2, R3 are described within the specification. The compounds act as anti- cancer agents by inhibition of HER-2 and EGFR.

La présente invention concerne des composés représentés par la formule (1), présentant la structure (I), dans laquelle R¿1?, R¿2? et R¿3? désignent des éléments décrits dans la partie descriptive de la présente demande. Ces composés agissent comme des agents anticancéreux et inhibent HER-2 et EGFR.

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