Tricyclic benzazepine vasopressin antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 495/14 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 471/14 (2006.01) C07D 491/147 (2006.01) C07D 498/14 (2006.01) C07D 513/14 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2210632

Tricyclic compound of general formula (I) as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.

On définit un composé tricyclique de la formule générale (I) qui montre une activité antagoniste aux récepteurs V1 et/ou V2 ainsi qu'une activité antagoniste de vasopressine in vivo. En outre, on décrit des méthodes d'utilisation de composés de ce type pour le traitement de maladies caractérisées par un excès de réabsorption de l'eau par le rein, ainsi qu'un processus de préparation de ces composés.

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