C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) C07K 1/04 (2006.01) C07K 4/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C12N 9/04 (2006.01) C12N 15/10 (2006.01) C12P 7/60 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/70 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2367313
A method for screening a low molecular weight substance which binds to a specific site of a biomolecule and thus may be usable as a starting material in developing drugs. This method comprises screening a substance which undergoes an interaction with a specific area of a biomolecule having an activity to thereby regulate the activity through the following steps: (a) the step of selecting a recombinant undergoing an interaction with the above- described biomolecule from a peptide library consisting of recombinants each presenting at least one of various peptides on the surface; and (b) the step of selecting a substance inhibiting the interaction between the recombinant thus selected or the peptide presented by this recombinant and the above biomolecule.
La présente invention concerne un procédé de criblage de substance de bas poids moléculaire qui se lie à un site spécifique d'une biomolécule et qui peut ainsi être utilisée comme matériau de départ dans le développement de médicaments. Ce procédé comprend le criblage d'une substance, qui interagit avec une partie spécifique d'une biomolécule active afin de réguler cette activité, à travers les étapes qui consistent à (a) choisir un recombinant interagissant avec ladite biomolécule à partir d'une banque de peptides consistant de recombinants qui présentent chacun au moins un des nombreux peptides de la surface, et (b) à choisir une substance qui inhibe l'interaction entre le recombinant sélectionné, ou le peptide présenté par ce recombinant, et la biomolécule.
Eto Yuzuru
Miwa Kiyoshi
Okamoto Satoru
Ajinomoto Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
LandOfFree
Method for screening biomolecule activity regulator does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for screening biomolecule activity regulator, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for screening biomolecule activity regulator will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1360125