Methods of producing anti-angiogenic proteins: endostatin,...

Details Methods of producing anti-angiogenic proteins: endostatin,... Methods of producing anti-angiogenic proteins: endostatin,...

C - Chemistry, Metallurgy

12

N

C12N 15/81 (2006.01) A61K 38/39 (2006.01) A61K 38/48 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C12N 9/68 (2006.01) C12N 15/12 (2006.01) C12N 15/52 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2312287

Methods for making proteins with anti-angiogenic properties are disclosed, including angiostatin, endostatin and restin. The system used is a yeast expression system which produces biologically active proteins at high titer, specifically the Pichia pastores yeast expression system.

Procédés de fabrication de protéines à propriétés angiogéniques, dont l'angiostatine, l'endostatine et la restine. Le système utilisé est un système d'expression de levure qui produit des protéines biologiquement actives à titre élevé, et plus spécifiquement le système d'expression de levure Phichia pastores.

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