Factor x analogues with a modified protease cleavage site

Details Factor x analogues with a modified protease cleavage site Factor x analogues with a modified protease cleavage site

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/48 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2282707

The invention relates to factor X analogues which have a modification in the area of the naturally occurring factor Xa activating cleavage site, said modification representing a processing site of a protease which does not naturally cleave in this area of the factor X sequence. The invention also relates to preparations containing the innovative factor X analogues and to methods for the production thereof.

L'invention concerne des analogues du facteur X ayant une modification naturelle dans la zone du site de clivage activant le facteur Xa. Cette modification représente un site de traitement d'une protéase clivant de manière non naturelle dans cette zone de la séquence du facteur X. L'invention concerne également des préparations contenant les analogues du facteur X de l'invention ainsi que leur procédé de production.

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