Novel galactose transferases, peptides thereof and nucleic...

Details Novel galactose transferases, peptides thereof and nucleic... Novel galactose transferases, peptides thereof and nucleic...

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A01K 67/027 (2006.01) A61K 31/711 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 15/12 (2006.01) C12N 15/54 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2480386

A novel galactose transferase C1Gal-T2 comprising an ORF of 957 bp and another novel galactose transferase C1Gal-T3 comprising an ORF of 948 bp are successfully identified. It is suggested that these enzymes are core 1 sugar chain (galactose .beta.1-3 acetylgalactosaminyl .alpha.1-R) synthases. These enzymes and polynucleotides encoding the same are expected as appropriately usable as remedies for diseases caused by failures in the expression or functions of these enzymes.

Une nouvelle galactose transférase C1Ga1-T2 comprenant un ORF de 957 bp ainsi qu'une galactose transférase C1Ga1-T3 comprenant un ORF de 948 bp ont été identifiées avec succès. On suggère que ces enzymes sont des synthases de chaîne de sucre de structure 1 (galactose .beta.1-3 acétylgalactosaminyl .alpha.1-R). Ces enzymes et les polynucléotides les codant sont supposés être utilisés de manière appropriée comme médicaments pour des maladies induites par des insuffisances dans l'expression ou les fonctions de ces enzymes.

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