Fused bicycloheterocycle substituted quinuclidine derivatives

Details Fused bicycloheterocycle substituted quinuclidine derivatives Fused bicycloheterocycle substituted quinuclidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2611674

Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N+-O-; X is O, S, - NH-, and -N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by .alpha.7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

L'invention concerne des composés représentés par la formule (I), dans laquelle n représente 0, 1, ou 2 ; A représente N ou N+-O- ; X représente O, S, -NH- et -N-alkyl- ; Ar1 représente un cycle aromatique à 6 chaînons ; et Ar2 représente un bicyclohétérocycle condensé. Lesdits composés sont utiles dans le traitement d'états pathologiques ou de troubles inhibés ou soulagés par des ligands a7 nAChR. L'invention concerne également des compositions pharmaceutiques présentant les composés représentés par la formule (I) ainsi que des méthodes d'utilisation desdits composés et desdites compositions.

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