Elevation of adenosine level by cytokine-induced expression...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/19 (2006.01) A61K 38/43 (2006.01) A61P 29/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2519465

This invention concerns a method of inducing an elevated level of adenosine in an individual by administering to said individual an effective amount of either i) recombinant protein CD73 or ii) a cytokine or another factor-being capable of inducing endothelial CD73 expression, or a combination thereof. Furthermore, the invention concerns a method for prevention or treatment of a disease or disorder requiring or benefiting from the elevation of the adenosine level in an individual, such as inflammatory conditions. Furthermore, the invention concerns a method of up-regulating endothelial CD73 expression in an individual by administering to said individual an effective amount of a cytokine or another factor being capable of inducing endothelial CD73 expression, and to a method for prevention or treatment of a disease or disorder requiring or benefiting from up-regulating endothelial CD73 expression.

L'invention concerne un procédé d'induction d'un niveau élevé d'adénosine chez un individu par administration audit individu d'une dose efficace soit de i) une protéine recombinée CD73 soit ii) une cytokine ou un autre facteur capable d'induire l'expression de CD73 endothéliale, ou une combinaison de celles-ci. De plus, l'invention concerne une méthode de prévention ou de traitement d'une maladie ou d'un trouble requérant ou tirant avantage de l'élévation du niveau d'adénosine chez un individu, tel que des états inflammatoires. En outre, l'invention concerne un procédé de régulation positive de l'expression de CD73 endothéliale chez un individu par administration audit individu d'une dose efficace d'une cytokine ou d'un autre facteur capable d'induire une expression de CD73 endothéliale, et une méthode de prévention ou de traitement d'une maladie ou d'un trouble requérant ou tirant avantage d'une régulation positive de l'expression de CD73 endothéliale.

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