N-substituted-1-amino-1,1-dialkylcarboxylic acid derivatives

Details N-substituted-1-amino-1,1-dialkylcarboxylic acid derivatives N-substituted-1-amino-1,1-dialkylcarboxylic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 311/46 (2006.01) A61K 31/165 (2006.01) A61K 31/18 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C07D 211/66 (2006.01) C07D 213/40 (2006.01) C07D 271/06 (2006.01) C07D 309/14 (2006.01) C07D 335/02 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2418173

The novel compounds of formula (I), wherein R1, R2, R2', R2", R3, R4, R5, R5', R5", R5''', R'''', X, Y, U, V and W have the meanings given in patent claim no. 1, are inhibitors of the coagulation factors Xa and VIIa and can be used for treating thromboses, myocardial infarction, arteriosclerosis, inflammations, apoplexy, angina pectoris, restenosis following angioplasty, intermittent claudication, tumours, tumour diseases and/or tumour metastases.

De nouveaux composés de la formule (I) où R?1¿, R?2¿, R?2'¿, R?2"¿, R?3¿, R?4¿, R?5¿, R?5'¿, R?5"¿, R?5'''¿, R?''''¿, X, Y, U, V et W ont la signification donnée dans la revendication 1. Ces composés sont des inhibiteurs du facteur de coagulation Xa et VIIa et peuvent être utilisés pour traiter la thrombose, l'infarctus du myocarde, l'artériosclérose, les inflammations, l'apoplexie, l'angine de poitrine,la resténose après angioplastie, la claudication intermittente, les tumeurs, les maladies tumorales et/ou les métastases tumorales.

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