Process for the chemical synthesis of oligonucleotides

Details Process for the chemical synthesis of oligonucleotides Process for the chemical synthesis of oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) C07C 315/04 (2006.01) C07C 317/36 (2006.01) C07C 317/48 (2006.01) C07H 19/04 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2051217

A process for the chemical synthesis of oligonucleotides Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. The ease of detection of the dansyl protective group and the ease of elimination from the sugar residue of the nucleotide without side reactions make oligonucleotide synthesis possible with high yields in very small quan- tities.

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