C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2661803
Provided is a monoclonal antibody, or an antigen binding fragment thereof, which binds specifically to an epitope within the sequence KPGAKKDTKDSRPKL (Sequence ID No. 2) of AGR2. Such monoclonal antibodies are of prognostic and diagnostic utility in the investigation of cancer, particularly metastatic cancer. The antibodies described may also be used in prognosis or diagnosis of inflammatory diseases. Also provided are kits and solid supports comprising such antibodies, as well as the therapeutic use of antibodies of the invention.
L'invention concerne un anticorps monoclonal, ou un fragment Fab de celui-ci, qui se lie spécifiquement à un épitope dans la séquence KPGAKKDTKDSRPKL (SEQ ID No. 2) de l'AGR2. Ces anticorps monoclonaux présentent une utilité pronostique et diagnostique dans la recherche sur le cancer, et notamment le cancer métastatique. Lesdits anticorps peuvent également être utilisés dans le pronostic ou le diagnostic de maladies inflammatoires. L'invention concerne également des trousses et des supports solides comprenant ces anticorps, ainsi que l'utilisation thérapeutique d'anticorps de l'invention.
Barraclough Dong Liu
Barraclough Roger
Rudland Philip
Marks & Clerk
The University Of Liverpool
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