Methods for effecting neuroprotection

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/41 (2006.01) A61K 31/198 (2006.01) A61K 31/415 (2006.01) A61K 31/4178 (2006.01) A61K 38/11 (2006.01) A61K 38/55 (2006.01) A61P 9/10 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2403555

The present invention relates to methods for preventing damage to excitable cells following ischemic by administering to a patient who is undergoing or who has undergone an ischemic event an effective amount of a compound which increases a transient potassium (K+) conductance in the excitable cells of the patient. The present invention also provides a method for screening for compounds which increase a transient K+ current in the excitable cells of a patient.

L'invention concerne des procédés visant à prévenir des lésions de cellules excitables suite à une ischémie, par l'administration à un patient atteint ou ayant été atteint d'ischémie d'une quantité efficace d'un composé qui accroît une conductibilité transitoire du potassium (K?+¿) dans les cellules excitables du patient. L'invention concerne aussi un procédé de criblage de composés qui accroissent un courant transitoire K?+¿ dans les cellules excitables d'un patient.

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