Injection vehicle for polymer-based formulations

Details Injection vehicle for polymer-based formulations Injection vehicle for polymer-based formulations

A - Human Necessities

61

K

A61K 47/36 (2006.01) A61K 9/16 (2006.01) A61K 38/00 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2387058

The invention provides injection vehicles suitable for administering particulate suspensions, such as polymer-based formulations, as well as associated pharmaceutical formulations, articles of manufacture, and kits. Other aspects of the invention included methods for producing and administering pharmaceutical formulations. The injection vehicles of the invention are superior to conventional injection vehicles in that they include a pseudoplastic composition that improves injectability, which facilitates delivery of the desired dose. The injection vehicles of the invention also allow the use of smaller-bore needles than are usually necessary to inject polymer-based formulations, reducing the pain associated with injection of such formulations.

La présente invention concerne des excipients d'injection permettant l'administration de suspensions de particules, telles que des formulations à base de polymères, ainsi que des formulations pharmaceutiques associées, des articles de fabrication et des nécessaires. D'autres réalisations de l'invention concernent des procédés de production et d'administration de formulations pharmaceutiques. Les excipients d'injection de l'invention sont supérieurs aux excipients d'injection classiques parce qu'ils comprennent une composition pseudoplastique qui permet d'améliorer les propriétés d'injection, ce qui facilite la délivrance de la dose recherchée. Les excipients d'injection de l'invention permettent aussi l'utilisation d'aiguilles de plus petit calibre, contrairement à ce qu'il est nécessaire d'utiliser habituellement pour injecter des formulations à base de polymères, réduisant ainsi la douleur associée à l'injection de telles formulations.

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