Thiazolidinedione derivative and its use as antidiabetic

Details Thiazolidinedione derivative and its use as antidiabetic Thiazolidinedione derivative and its use as antidiabetic

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/427 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2370262

A polymorphic form of 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt (the "Polymorph") characterised in that it provides: (i) an infra red spectrum containing peaks at 1752, 1546, 1154, 621, and 602 cm-1; and/or (ii) a Raman spectrum containing peaks at 1751, 1243 and 602 cm-1; and/or (iii) a solid- state nuclear magnetic resonance spectrum containing peaks at 111.9, 114.8, 119.6, 129.2, 134.0, 138.0, 144.7, 153.2, 157.1, 170.7, 172.0 and 175.0 ppm; and/or (iv) an X-ray powder diffraction (XRPD) pattern which gives calculated lattice spacings of 6.46, 5.39, 4.83, 4.68, 3.71, 3.63, 3.58, and 3.48 Angstroms; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.

Forme polymorphe de 5-[4-[2-(N-méthyle-N-(2-pyridyl)amino)éthoxy]benzyl]thiazolidine-2,4-dione, sel d'acide maléique (le <= polymorphe >=) caractérisée par le fait qu'elle produit : (i) un spectre infrarouge contenant des crêtes à 1752, 1546, 1154, 621 et 602 cm?-1¿; et/ou (ii) un spectre de Raman contenant des crêtes à 1751, 1243 et 602 cm?-1¿; et/ou (iii) un spectre de résonance magnétique nucléaire par semi-conducteur contenant des crêtes à 111,9, 114,8, 119,6, 129,2, 134, 138, 144,7, 153,2, 157,1, 170,7, 172 et 175 ppm ; et/ou (iv) une configuration de diffraction de poudre aux rayons X (XRPD) produisant des espacements de réseau calculés de 6,46, 5,39, 4,83, 4,68, 3,71, 3,63, 3,58 et 3,48 Angströms ; procédé servant à préparer ce composé, composition pharmaceutique contenant ce composé et son utilisation médicale.

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